Stress and pain responses are largely controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems, with many of these signals conveyed through activation of neuropeptide (i.e., CRF, Opioid) and monoamine (i.e., Dopamine, Serotonin, Norepinephrine) receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they can stimulate a variety of signaling cascades following neurotransmitter release and receptor binding.  To expand our knowledge of the brain and to identify novel treatments for physiological and psychological diseases, the Bruchas laboratory is primarily interested in discovering how neuropeptide and monoamine G-protein coupled receptor (GPCR) systems function in the contexts of stress, depression, addiction, and pain. We use genetic, pharmacological, optogenetic, and behavioral approaches to determine the role of these receptor systems in neural circuits and central nervous system function.
          The Bruchas Lab

G-protein Coupled Receptor / 7TM Receptor (top) knockout mice (below)

St. Louis (top), Wash U Med Center (below)

Department of Anesthesiology | Washington University School of Medicine | Box 8054 St. Louis, MO 63110 USA